Neptune Krill oil - Huile de krill de Neptune processed by Neptune Technologies and Bioressources Inc

Neptune Krill Oil 500 mg 60 softgels

Cardiovascular Benefits

In human studies, Neptune Krill Oil has been shown to help maintain blood lipid levels - LDL, HDL, total cholesterol, and tryglycerides - already in the normal range.  . 

Neptune Krill Oil

The results of a recent study have shown with a high level of certainty that Neptune Krill Oil, at a daily dose of 300 mg, may significantly inhibit by reducing C-reactive protein (CRP). 

After taking Neptune Krill Oil 500 mg/day for a period of 7, 14, and 30 days, CRP was reduced 19.3%, 29.7% and 30.9%.  In this study, 90 patients with cardiovascular disease, rheumatoid arthritis or osteoarthritis and with increased levels of C-reactive protein >1.0 mg/dl were evaluated.  Patients were split into a Krill Oil group and those taking placebo.  The Western Ontario and McMaster (WOMAC) University Osteoarthritis index was administered to validate the results.

Quality of Life

Woman's World said: "Krill oil is so potent, women who took it for three months reported a 51% boost in energy, alertness, memory, concentration and stamina in a recent Canadian study.  And almost 100% described having a greater sense of well-being and happiness -- plus a 31% reduction in aches and pains!"

These figures were derived from a quality of life study comparing the benefits of Neptune Krill Oil to Fish Oil.  The quality of life study was done in conjunction with the Phase II clinical trial "Evaluation of the effectiveness of NKO on the clinical management of  Hyperlipidemia."  In the study, 120 participants, including both men and women, took either 1.0 or 1.5 grams of krill oil per day (based on their BMI [body mass index]) or 3.0 grams per day of fish oil.  Study participants took a 36-question standardized survey at the end of 30 days, 90 days, and 180 days.  This survey measured the patients physical function, fatigue, pain, social function, emotional role, mental capacity, general health and physical appearance.  The survey, in use since 1998 and published in over 4,000 different studies, was designed to provide statistically valid results.  

Please note that study participants took 2 or 3 -- 500 mg krill oil softgels daily for a period of 90 days to obtain the results reported in this study.  Those with a BMI (body mass index) less than 32 took 2 softgels daily; those with a BMI greater than 32 took 3 softgels daily.


Anti Aging Benefits

One interpretation of the high antioxidant value of Rejuvenation Science Neptune Krill Oil comes from Woman's World magazine: "Krill is a unique oil that is rich in Omega-3 fatty acid, which repairs aging cells so well, studies show it's up to 300 times more rejuvenating than vitamins A and E!"

This claim was derived from the ORAC (Oxygen Radical Absorbance Capacity) studies, which measure the antioxidant power of various nutrients.  The ORAC Value chart below shows that Krill Oil has a value which is 300 times as high as either vitamin A or vitamin E, and 47 times higher than fish oil.  

Krill Oil Safety

Omega-3 Fatty Acids - A recent review on the safety of omega-3 fatty acids by the US Food and Drug Administration concluded that a daily intake of EPA and DHA of up to 3 g is generally recognized as safe. Dosages as high as 3 g to 8 g of omega 3 fatty acids per day (from 10 g to 27 g fish oil) show virtually no significant adverse effects3. The most common side effects observed with fish oil capsule consumption are complaints of a fishy taste and belching of fish flavors. At relatively higher doses, as with any oil, gastrointestinal complaints including loose stools have been reported.

Although there has never been a reported case of clinical bleeding attributed to fish oil consumption even during surgery, obvious consideration should be given to patients with bleeding disorders and patients taking blood thinners or anticoagulants 4,5,6.

Krill Oil - Long-term Krill Oil safety has been evaluated with a 6-month animal study using mice.  Six months in mice lifespan is equivalent to 27 human years.  The mice were fed krill oil amounting to 16.6% of their daily diet. Human equivalent dosage corresponds to 23.1 grams of krill oil (for a 70kg or 154 pound person) or 7- 11 times the recommended dose. No adverse effects were reported. No pathological findings upon examination of brain, lungs, heart, stomach, pancreas, liver, kidneys, uterus / prostate, intestine, or skin. 

The results of the present toxicity assessment confirm that Neptune Krill Oil can be considered as safe for human consumption even at 2 to 3 times the highest recommended dose.

Note: People with a known allergy to fish or seafood were not tested in this study. The precaution remains that in the case of fish or seafood allergies, professional allergy testing is advised prior to consumption of Neptune Krill Oil.


How Krill Oil is Produced

Krill are small shrimp or prawn-like crustaceans, habitants of oceans off the West coast of Vancouver Island, Russia, Ukraine and Japan. Approximate area of distribution at the Circumpolar in Antarctic waters is 35 million square kilometers.  Approximately 90 species have been recognized, most of which range in length from 8 to 70 mm (mean length 16 mm.). Considering a population size of 500 million tons, Krill are the most important Zooplankton group in the world oceans after Copepods.  Major predators are Baleen whales (blue, fin, mink), crabeater seals, fur seals, Adelie and macaroni penguins, petrels, fulmars and shearwaters, squid and fish. In Japan humans consume them as an ethnic delicacy.  Euphasia Pacifica, commonly known as Krill, make up the order of Euphausiacea, subclass of Malacostraca, class of Crustacea and phylum of Anthropoda

NKO is extracted from the body of Krill with an innovative process of lipid extraction which produces a dehydrated residue. The most significant components of NKO are the Omega-3 fatty acids, containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), all-trans retinol or vitamin A, vitamin E, Astaxanthin and Canthaxanthin.  Scientific evidence suggests that Omega-3 and antioxidants may have both preventive and therapeutic properties for systemic disease, mainly cardiovascular and neoplastic.


For Medical Professionals

The omega-3 fatty acids in Rejuvenation Science Neptune Krill Oil, which are almost exclusively EPA and  DHA, come in the form of PHOSPHOLIPIDS contrary to all other marine oils where the fatty acids are in a triglyceride form. NKO has a particular molecular structure with EPA and DHA occupying the two fatty acid chains of the phospholipids. This makes the omega-3 in the Neptune Krill Oil significantly more bioavailable than fish oils because it allows the direct entrance of EPA and DHA into the cells. This is a fact that is proven in the Phase II clinical trial: Evaluation of the effectiveness of NKO on the clinical management of Hyperlipidemia". The results of this clinical trial clearly demonstrate that 1g of NKO as a booster and a maintenance dose of 0.5g is significantly more effective for the regulation of blood lipids and glucose than 3g maximum EPA-DHA fish oil.

The astaxanthin and the flavonoid in NKO esterify with a double bond with the EPA and the DHA respectively. This esterification allows the direct metabolism of the antioxidants making them more bioavailable than other antioxidants on the market.

Because of the abundance of phospholipids in NKO it passes through the stomach and is digested in the small intestine. This explains the fact that even at 12 times the DRI (daily recommended intake) there has been no reported incident of regurgitation. This eliminates the most frequent side effect of fish oils which is the fishy aftertaste and frequent reflux.

NKO is free of heavy metals, PCBs, dioxins and pesticides.

All of the above make NKO the ultimate Omega-3 marine product, offering remarkable safety, stability, effectiveness, bioavailability, scientific validation and all at a competitive price.

Peroxide Value

This is the classic test for measuring oxidation in fresh oils. A peroxide value over 2 is an indicator that the product has a high rancidity potential and could fail on the shelf.

                    Neptune Krill Oil´┐Ż Peroxide value = 0.05 mEq peroxide/kg

Oil Stability Index (OSI)

All oils and fats have a resistance to oxidation, which depends on the degree of saturation, natural or added antioxidants or prior abuse. Oxidation is slow until this resistance is overcome, at which point oxidation accelerates and becomes very rapid. The length of time before this rapid acceleration of oxidation is the measure of the resistance to oxidation and is commonly referred to as the induction period or Oxidative Stability Index.

       NKO OSI = Peroxide value <0.05 for over 50 hrs at 97.8oC (208oF)


NKO is clinically validated for men and women to enhance:
For Men and Women • Lipid Management - NKO™ supports healthy blood lipids.
• Brain Nutrition - NKO™ contains ultra-potent marine lipids which enhance brain function.

Additional Benefits For Women
• Menstrua Discomforts - NKO™ relieves emotional and physical menstrual discomforts

Nutrition Facts:

New Exciting Research on Krill Oil

A recently published double-blind, controlled, randomized trial on 70 women showed that Krill Oil dramatically improved all emotional PMS symptoms including feeling overwhelmed, anxiety, stress, irritability, and depression. After 45 and 90 days the NKOTM Krill Oil group on 2 g per day, had statistically significant differences in both emotional and physical symptoms including breast tenderness, joint pain and dysmenorrhea. The fish oil group after 90 days only had statistically significant reduction in weight gain, swelling and abdominal pain. (14) Study subjects reported using 50% fewer analgesics on a dose of 2 Krill Oil gelcaps daily. A recent study on 120 human subjects (results to be published) compared the effects of Fish oil vs. Krill Oil on hyperlipidemia. Krill Oil at a dose of 1.5 grams per day was more effective than fish oil at reducing glucose levels, total cholesterol, LDL, Cho1:HDL ratio and at raising HDL levels. A 3 g dose of Krill Oil daily lowered triglyceride levels as well. A mice study showed that Krill Oil can significantly prevent the incidence of skin cancer caused by chronic exposure to UV radiation.

As if that's not enough, Krill Oil also contains sphingomyelin, a component of myelin sheath that surrounds nerve cells. Research on Krill Oil's ability to improve MS and mercury's damage to nerve cells is surely needed.


A recent review on the safety of omega-3 fatty acids by the US FDA concluded that a daily intake of EPA and DHA of up to 3 g is GRAS (generally recognized as safe). Dosages as high as 3-8 g of omega-3 fatty acids per day show virtually no significant adverse effects. (15-17) Safety studies on mice reveal no adverse effects from Krill Oil when given the human equivalent of 9 g of EPA and DHA per day, or 7-11 times the recommended dose for 6 months. 25 adult human volunteers were given 2 gelcaps of Neptune Krill Oi1TM three times per day for 2 months. Each gelcap contains 1 gram of Krill Oil. No serious side effects or negative changes in blood chemistry occurred. Some of the observed benefits include increased ability to concentrate, decreased seasonal allergy symptoms, increased skin hydration, improved hair texture, decreased joint discomfort and minimized PMS emotional and physical symptoms. Krill Oil has been proven safe even at dosages as high as 10 grams per day.


Not to be taken by shrimp allergic individuals. May decrease need for blood thinning medications such as Coumadin or Warfarin. Not recommended prior to surgery.

More info



Evaluation of the effects of Neptune Krill Oil on the Clinical Course of Hyperlipidemia.  JSS medical research inc. June 7, 2003

Flanigan J, Brunswick Laboratories, Wareham, MA

Stone NJ. Fish consumption, fish oil: lipids, and coronary heart disease. Circulation. 1996;94:2337-2340.

Simopoulos AP. Omega 3 fatty acids in health and disease and in growth and development. Am J Clin Nutr. 1991;54:438-463.

Saynor R, Verel D, Gillott T. The long term effect of dietary supplementation with fish lipid concentrate on serum lipids, bleeding time, platelets and angina. Atherosclerosis. 1984;50:3-10.

Knapp HR. Dietary fatty acids in human thrombosis and hemostasis. Am J Clin Nutr. 1997;65(suppl):1687S-1698S.

Neptune Technologies and Bioresources, Inc.,

Tina Sampalis MD, PhD. Private Correspondence to Rejuvenation Science, May 19, 2004.

Sampalis T, Evaluation of the Effect of NKO on Biomarkers of Chronic Inflammation in vivo.  JSS medical research, inc. June 9, 2004, unpublished.

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